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| Product Name | Otoraplin, Recombinant, Human |
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| Description | Purity ~98% (SDS-PAGE, HPLC). TOR proteins is also known as fibrocyte-derived protein (Fdp) and Melanoma inhibitory activity-like (MIAL). Otoraplin is a member of the melanoma-inhibiting activity gene family. Otoraplin is a secreted 16kD globular protein that is expressed in the inner ear by periotic mesenchyme and developing and mature fibrocytes. OTOR is highly homologous to MIA/cartilage-derived retinoic acid-sensitive protein (CD-RAP), which is a cartilage-specific protein that is also expressed in malignant melanoma cells. The 111aa mature human otoraplin contains 1 SH3 domain (aa46-107) and a Tyr at position 50 that is reportedly sulfated. Otoraplin takes part in the initiation of periotic mesenchyme chondrogenesis. Otoraplin is secreted through the Golgi apparatus and plays a role in cartilage development and maintenance. A frequent polymorphism in the translation start codon of OTOR can abolish translation and may be associated with forms of deafness. Source: Recombinant protei |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Otoraplin, Recombinant, Human (OTOR, Fibrocyte-derived Protein, Melanoma Inhibitory Activity-like Protein, MIAL, FDP, MIAL1, MGC126737, MGC126739) |
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| Gene, Accession, CAS # | OTOR, Gene ID: 56914, SwissProt: Q9NRC9 |
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| Catalog # | 220120 |
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| Order / More Info | Otoraplin, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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