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| Product Name | HSPA1A, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Heat Shock 70kD Protein (HSP70), also known as Heat Shock 70kD Protein 1A (HSPA1A), is a 641 amino acid (aa) member of the HSP70 family of molecular chaperones with a predicted molecular weight of 70kD. Human HSP70/HSPA1A shares 95% and 97% aa sequence identity with the mouse and rat orthologs, respectively. It has an Nterminal nucleotidebinding domain, which contains ATPase activity, and a Cterminal substratebinding domain (1). HSP70/HSPA1A promotes the proper folding of nascent polypeptides and assists in the refolding of denatured proteins (2). However, if either of these processes proceeds too slowly or fails, HSP70/HSPA1A can interact with the HSP40 cochaperone protein and the CHIP/STUB1 Ubiquitin ligase (E3) to promote ubiquitination and degradation of the nascent polypeptide or denatured protein (3,4). HSP70/HSPA1A can be regulated posttranslationally via multiple mechanisms, including phosphorylation, ubiquitination, and methylation (58). For exam |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HSPA1A, Recombinant, Human (HSP70, HSP70-1A, HSP72, Heat Shock 70kD Protein, Heat Shock 70kD Protein 1A) |
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| Gene, Accession, CAS # | Accession: AAD21816 |
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| Catalog # | 145803 |
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| Order / More Info | HSPA1A, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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