| 产品详情 |
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| Product Name | HSP70 Activator II, YM-08 |
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| Description | Purity ~99% (HPLC). A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30uM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 inuM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72h). Formula: C19H17N3OS2 Solubility: DMSO Primary Target: HSP70 Primary Target IC50: 0.6uM |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HSP70 Activator II, YM-08 ((2Z,5E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-ylmethylene)thiazolidin-4-one, Heat Shock 70kD Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217442 |
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| Order / More Info | HSP70 Activator II, YM-08 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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