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| Product Name | Human IRF8 Synthetic Peptide |
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| Description | Human IRF8 Synthetic Peptide. IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B. |
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| Size | 50 ug |
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| Concentration | n/a |
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| Applications | Blocking Assay: Assay Dependent, Control: Assay Dependent |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Entrez: 3394; Uniprot: Q02556 |
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| Catalog # | PEP-0206 |
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| Price | |
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| Order / More Info | Human IRF8 Synthetic Peptide from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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