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| Product Name | Recombinant Dendroaspis angusticeps Fasciculin-2 (Fas-2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 22.8kDa. Full Length: 1-61aa. N-terminal 6xHis-SUMO-tagged. Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps). Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations. It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme (through the Met-33 residue), thereby preventing its breakdown. It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Short name:Fas-2; Short name:Fas2; Alternative name (s); Acetylcholinesterase toxin F-VII; Fasciculin-II; Short name:FAS-II; Toxin TA1 |
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| Gene, Accession, CAS # | Fas-2, UniProt: P0C1Z0 |
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| Catalog # | RPC22381 |
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| Order / More Info | Recombinant Dendroaspis angusticeps Fasciculin-2 (Fas-2) from BIOMATIK |
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| Product Specific References | n/a |
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