| 产品详情 |
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| Product Name | RKI-1447 |
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| Description | A ROCK-I and II inhibitor (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase; suppresses the activation of ROCK substrates MLC-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 at 100 nM in cancer cells |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1342278-90-3 1342278-94-7 ROCK inhibitor cancer migration invasion metastasis Rho-associated kinase ROCK1 ROCK2 biochemical signal transduction intracellular signaling RKI1447 ATP binding site suppress activation substrate myosin light chain MLC-2 phosphatase PP1 MLC2 regulatory subunit MYPT-1 MYPT1 mediated MDA-MB-231 breast cancer cells pyridylthiazolyl-urea |
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| Gene, Accession, CAS # | CAS: 1342278-01-6 |
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| Catalog # | 16278-50 |
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| Order / More Info | RKI-1447 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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