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| Product Name | Recombinant Porcine CXCL8/IL-8 (carrier-free) |
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| Description | IL-8 (CXCL8) was originally recognized as a neutrophil-activating protein on the basis of two in vitro effects, chemotaxis and the release of granule enzymes. Porcine IL-8 is generated as a precursor of 103 amino acids. Porcine IL-8 is 75 and 81% similar to human and rabbit IL-8, respectively. IL-8 is one of the ELR (Glu-Leu-Arg) motif-positive CXC-chemokines and shares similarities with angiogenic cytokines. The ELR motif is just before the characteristic CXC sequence of cysteine residues. Most of the chemokines form noncovalent dimers, and IL-8 is functional as a monomer and as a dimer. The monomeric form binds with higher affinity to the CXCR1 than the dimeric form. IL-8 binds to CXCR1 and CXCR2. CXCR1 is shared with CXCL6 and CXCR2 is shared with CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL7. The CXCR1 receptor has two binding sites for IL-8, the binding site I located in the amino terminal domain, and the binding site II that includes one or two extracellular loops of CXCR1. IL-8/CXCR1 interaction induces tumor proliferation, and IL-8/CXCR2 interaction promotes angiogenesis in prostate cancer. |
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| Size | 5 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Small inducible cytokine subfamily B, member 8 (SCYB8), Monocyte derived neutrophils chemotactic factor (MDNCF), Neutrophil-activating peptide 1 (NAP1), Granulocyte chemotactic protein 1 (GCP1), Chemokine, CXC motif, ligand 8 |
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| Gene, Accession, CAS # | Gene ID: 396880 |
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| Catalog # | 782901 |
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| Order / More Info | Recombinant Porcine CXCL8/IL-8 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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