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| Product Name | Poly A Specific Ribonuclease (PARN) protein (His tag) |
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| Description | DNA toposisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in Scleroderma patients (specificity 98-100 %) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis.In human tissues the DNA topoisomerase I is initially synthesized as a protein with 100 kDa molecular weight. Most of this precursor is then proteolytically processed to a species with 70 kDa molecular weight from which the Scl-70 antigen has derived its name Synonyms: DNA topoisomerase 1, EC 5.99.1.2, DNA topoisomerase I, TOP1, Scl-70 |
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| Size | 5 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | parn-A|xparn|DAN|RGD1565449|zgc:56067|1200003I18Rik |
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| Gene, Accession, CAS # | Gene ID: 5073 |
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| Catalog # | ABIN805472 |
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| Order / More Info | Poly A Specific Ribonuclease (PARN) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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