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| Antigenic Specificity | Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (aa 145-160), (Middle Region) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BMPR1B(Bone Morphogenetic Protein Receptor Type IB), also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. BMPR1B is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al.(1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al.(1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue. |
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| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human BMPR1B(145-160aa FCYFRYKRQETRPRYS), different from the related rat and mouse sequences by one amino acid. |
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| Other Names | ALK6|BMPR-IB|FecB|alk-6|alk6|cdw293|alk6b|zgc:172219|BMPR1B|AI385617|ALK-6|AV355320|Acvrlk6|Alk6|BMPR-1B|CFK-43a|SKR6|BR1b|alk6tr|bmpr1b|zALK-6|zgc:92220|CDw293|BMP15|BMPRIB|RPK-1 |
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| Gene, Accession # | Gene ID: 658 |
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| Catalog # | ABIN1673502 |
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| Order / More Info | Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (aa 145-160), (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 9178898, 15805157, 10051328 |
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