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| Product Name | Recombinant Human Eukaryotic translation initiation factor 3 subunit E (EIF3E) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 79.1kDa. Full Length: 1-445aa. N-terminal GST-tagged. Homo sapiens (Human). omponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Eukaryotic translation initiation factor 3 subunit 6; Viral integration site protein INT-6 homolog; eIF-3 p48 |
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| Gene, Accession, CAS # | EIF3E, UniProt: P60228 |
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| Catalog # | RPC21250 |
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| Order / More Info | Recombinant Human Eukaryotic translation initiation factor 3 subunit E (EIF3E) from BIOMATIK |
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| Product Specific References | n/a |
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