| 产品详情 |
| Edit |   |
|---|
| Product Name | CFI-402257 |
|---|
| Description | An orally bioavailable inhibitor of MPS1/TTK (IC50 = 1.7 nM); selective for MPS1/TTK over a panel of 262 kinases at 1 µM; increases aneuploidy in HCT116 cells at >100 nM; inhibits cell growth in a panel of breast, ovarian, prostate, pancreatic, lung, and colon cancer cell lines (GI50s = 0.001-1.3 µM); reduces tumor growth in HCT116 and HT29 mouse xenograft models as well as platinum-resistant and -sensitive high-grade serous ovarian cancer PDX mouse models at 6.5 mg/kg; inhibits CYP2C9 and CYP2C19 (IC50s = 13 and 8 µM, respectively) as well as CYP3A4 metabolism of BFC and DBF (IC50s = 0.51 and 14 µM, respectively) |
|---|
| Size | 5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | CFI402257 MPS-1 HCT-116 HT-29 CYP-2C9 2C19 3A4 |
|---|
| Gene, Accession, CAS # | CAS: 1610759-22-2 |
|---|
| Catalog # | 21960-5 |
|---|
| Price | |
|---|
| Order / More Info | CFI-402257 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|