| 产品详情 |
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| Antigenic Specificity | KEAP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 100ul |
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| Concentration | 1ug/ul |
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| Applications | WB, IHC-P, IF(IHC-P) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | KEAP1 Polyclonal Antibody. • Target Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
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| Immunogen | KLH conjugated synthetic peptide derived from human KEAP1. Immunogen Range: 75-125/624 |
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| Other Names | INrf2; KLHL19; Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Kelch-like protein 19; KEAP1; KIAA0132 |
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| Gene, Accession # | Gene ID: 9817, SwissProt: Q14145 |
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| Catalog # | bs-3648R |
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| Price | |
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| Order / More Info | KEAP1 Antibody from BIOSS ANTIBODIES |
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| Product Specific References | Su, Chuanyang, et al. (2015) Chem Res Toxicol. PubMed: 25742418 // Su, Chuanyang, et al. (2015) J Agric Food Chem. PubMed: 25978654 // Chen, Ya-Hui, et al. (2016) PLoS ONE 11.4: e0154210. PubMed: 27124120 // Su, Chuanyang, et al. (2017) Toxicology. PubMed: 28645578 // Kouam et al. (2017) Front.Pharmacol. 8:653. PubMed: 28974930 |
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