| 产品详情 |
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| Antigenic Specificity | NIK |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | 0.2 mg/ml |
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| Applications | Western blot |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Polyclonal Antibody to detect NIK in Human, Mouse, Rat samples. NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK was initially isolated from a human B cell cDNA library and contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to IkB phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation. |
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| Immunogen | E. coli expressed recombinant human NIK fragment (a.a. 795-947). |
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| Other Names | MAP3K14 |
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| Gene, Accession # | Gene ID: 9020, Accession: Q99558 |
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| Catalog # | 3193-100 |
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| Price | |
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| Order / More Info | NIK Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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