| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | IL-33 |
|---|
| Clone | 12H6D12 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 5 µg/mL, Western Blot: 1 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | IL-33 Monoclonal Antibody (12H6D12). IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by |
|---|
| Immunogen | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | Entrez: 77125, 90865; Uniprot: O95760, Q8BVZ5 |
|---|
| Catalog # | MA5-15773 |
|---|
| Price | |
|---|
| Order / More Info | IL-33 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|