| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | IL-17F |
|---|
| Clone | 6B9.H8 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, mouse (based upon sequence alignment) |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Purified anti-IL-17F. Interleukin 17F (IL-17F) is a 37 kD IL-17 family member. The IL-17 family consists of six members including IL-17 (also called IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17F shares the strongest similarity to IL-17A and forms a homodimer or heterodimer with IL-17A. It is produced by Th17 cells, mast cells, basophils, and epithelial cells. IL-17F is an important regulator of inflammatory responses. It is involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. Overexpression of the IL-17F gene in the airways of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. IL-17F is also involved in cancer immunity and autoimmune responses. IL-17F, like IL-17A, depends on IL-17R for its signaling in vitro and in vivo. P38 MAPK, ERK1/2, Act1 (NF-kB activator protein 1), and TRAF6 are involved in IL-17F signaling. |
|---|
| Immunogen | This monoclonal antibody was raised against a peptide sequence conjugated to KLH corresponding to amino acids 107-120 of human IL-17F protein. |
|---|
| Other Names | Interleukin-17F, IL-24, cytokine ML-1, mutant IL-17F, interleukin-24, MMS-5118-100 |
|---|
| Gene, Accession # | Gene ID: 112744 |
|---|
| Catalog # | 830201 |
|---|
| Price | |
|---|
| Order / More Info | IL-17F Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|