| 产品详情 |
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| Antigenic Specificity | CD317 |
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| Clone | RS38E |
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| Host Species | Mouse |
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| Reactive Species | human, African green, baboon, cynomolgus, pigtail, rhesus macaque |
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| Isotype | IgG1, κ |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | APC anti-human CD317 (BST2, Tetherin). CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation. |
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| Immunogen | n/a |
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| Other Names | BST2, Tetherin, HM1.24 |
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| Gene, Accession # | Gene ID: 684 |
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| Catalog # | 348410 |
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| Price | |
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| Order / More Info | CD317 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 21917971,22729361 |
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