| 产品详情 |
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| Antigenic Specificity | ASAP2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 20 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ASAP2 Polyclonal Antibody. ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Us |
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| Immunogen | n/a |
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| Other Names | AMAP2, centaurin, beta 3, CENTB3, DDEF2, development and differentiation enhancing factor 2, development and differentiation-enhancing factor 2, KIAA0400, PAG3, PAP, Pap-alpha, paxillin-associated protein with ARF GAP activity 3, PYK2 C terminus-associated protein, pyk2 C-terminus-associated protein, SHAG1 |
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| Gene, Accession # | Entrez: 8853; Uniprot: O43150 |
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| Catalog # | A303-311A-T |
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| Price | |
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| Order / More Info | ASAP2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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