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| Antigenic Specificity | Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) |
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| Clone | ALC1-1 |
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| Host Species | n/a |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunofluorescence (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD49d (Anti-VLA-alpha-4) recognizes the 150 kDa alpha-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of alpha and beta subunits and is involved in cell-cell and cell-extracellular matrix interactions. The beta-chain of the VLA-4 complex is the CD29 antigen, a 130 kDa glycoprotein. The CD29 antigen, also known as the beta-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B- lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the beta integrin, forms a lymphocyte homing receptor for Peyer's patch, binding to the mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3- dependent CD4+ T-lymphocyte activation via its interaction with fibronectin. |
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| Immunogen | n/a |
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| Other Names | LOC100219853|CD49D|IA4 |
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| Gene, Accession # | Gene ID: 3676 |
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| Catalog # | ABIN1112175 |
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| Order / More Info | Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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