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| Antigenic Specificity | Vascular Cell Adhesion Molecule 1 (VCAM1) |
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| Clone | 1-G11B1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | fluorescein (FITC) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD106, also known as INCAM-1, is a 100-110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages and bone marrow stromal cells. Endothelial CD106 binds the integrins 41 (CD49d/CD29, VLA-4) and 47 and contributes to extravasation of lymphocytes, monocytes, basophils and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the 2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. |
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| Immunogen | n/a |
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| Other Names | fi76d06|wu:fi76d06|zgc:158875|VCAM1|CD106|INCAM-100|Vcam-1|VCAM1B |
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| Gene, Accession # | Gene ID: 7412 |
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| Catalog # | ABIN135717 |
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| Price | |
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| Order / More Info | Vascular Cell Adhesion Molecule 1 (VCAM1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 8476577, 1702807 |
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