| 产品详情 |
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| Antigenic Specificity | TNF |
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| Clone | cA2 |
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| Host Species | Recombinant |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | Protein A purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | ELISA; in vivo; FC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Monoclonal antibody to detect TNF alpha in human samples. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defecti |
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| Immunogen | Purified recombinant human TNF (rTNF) |
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| Other Names | TNF-α; TNFα; TNFSF; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; TNFa |
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| Gene, Accession # | Gene ID: 7124, Accession: P01375 |
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| Catalog # | A1097-200 |
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| Price | |
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| Order / More Info | TNF Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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