| 产品详情 |
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| Antigenic Specificity | C19ORF2 (aa 350-400) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human C19ORF2 polyclonal antibody for WB, IP. Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival sigaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity at mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
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| Immunogen | Synthetic peptide |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 8725, UniProt: O94763 |
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| Catalog # | CABT-BL614 |
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| Price | |
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| Order / More Info | C19ORF2 (aa 350-400) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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