| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | BACE |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | n/a |
|---|
| Format | ion exchange purified |
|---|
| Size | 100 µg |
|---|
| Concentration | 1 mg/ml |
|---|
| Applications | Western blot, Immunohistochemistry, ELISA |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | BACE Antibody (CT). Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-soµght beta-secretase was recently identified by several groups independently and designated beta-site APP cleav |
|---|
| Immunogen | A peptide corresponding to 17 amino acids at the CT of human BACE. |
|---|
| Other Names | BACE (CT). Asp2 |
|---|
| Gene, Accession # | Gene ID: 23621, Accession: P56817 |
|---|
| Catalog # | 5051-100 |
|---|
| Price | |
|---|
| Order / More Info | BACE Antibody from BIOVISION, INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|