| 产品详情 |
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| Antigenic Specificity | ER Alpha / Estrogen Receptor |
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| Clone | 6F11 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | supernatant |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC, IHC-Fr (1:40 - 1:60), IHC-P (1:40 - 1:80), WB (1:50 - 1:100) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ER Alpha / Estrogen Receptor Antibody (clone 6F11) LS-C11577. Recognizes the human estrogen receptor alpha chain (ERalpha), also known as the estradiol receptor or nuclear receptor subfamily 3 group A member 1. ERalpha is a ~65kD steroid hormone receptor containing an N-terminal. ligand independent transactivation domain, a DNA binding domain and a C-terminal ligand binding domain which overlaps with an. ERalpha binds to DNA as a homodimer and can also form heterodimers with Estrogen receptor beta The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formalin fixed, paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays, to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patients prognosis and the effectiveness of hormonal therapy. Has been used successfully for identification of ERalpha on breast cancer cell lysates using Western blotting and for the immunohistochemical detection of ERalpha in breast cancer tissues. |
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| Immunogen | Recombinant human estrogen receptor (alpha form). |
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| Other Names | ESR1, Era, ERalpha, Estrogen receptor, ER-alpha, Estrogen receptor 1, NR3A1, ER, ESR, ESRA, Estrogen receptor alpha |
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| Gene, Accession # | ESR1, Gene ID: 2099 |
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| Catalog # | LS-C11577 |
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| Price | |
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| Order / More Info | ER Alpha / Estrogen Receptor Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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