| 产品详情 |
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| Antigenic Specificity | CD40 |
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| Clone | HM40-3 |
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| Host Species | Armenian Hamster |
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| Reactive Species | mouse |
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| Isotype | IgM |
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| Format | purified, azide-free |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), Block, Costim, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LEAF™ Purified anti-mouse CD40. CD40 is a 48 kD type I transmembrane glycoprotein, also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39) expressed on activated T cells, is important in costimulation and immune regulation. The HM40-3 antibody has been reported to stimulate dendritic and B cell proliferation and block CD40-CD40L interactions. |
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| Immunogen | (BALB/c x NZB)F1 mouse-derived lymphoma WEHI 231 |
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| Other Names | Bp50, TNFRSF5 |
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| Gene, Accession # | Gene ID: 21939 |
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| Catalog # | 102908 |
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| Price | |
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| Order / More Info | CD40 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 21276089 |
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