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| Product Name | MCC-555 |
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| Description | Purity >98%. The peroxisome proliferator-activated receptor-Gamma (PPARGamma) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs), a group of structurally related synthetic agonists with antidiabetic actions in vivo . Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class. MCC-555 is a structural homolog of rosiglitazone and the other TZDs. MCC-555 binds with about 1/10 the affinity of rosiglitazone to PPARGamma. Despite this, MCC-555 is a more potent antidiabetic agent in whole animal experiments than rosiglitazone and several other prototypic TZDs; the ED50 value in these experiments was 2.7 mg/kg for MCC-555 compared with 7.1 mg/kg for rosiglitazone. MCC-555 is therefore a unique new member of the TZD class and may be useful in differentiating some of the multiple activities attributed to this class of compounds. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione, Isaglitazone, Netoglitazone, RWJ 241947 |
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| Gene, Accession, CAS # | CAS: 161600-01-7 |
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| Catalog # | LS-H8608 |
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| Price | |
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| Order / More Info | MCC-555 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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