| 产品详情 |
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| Product Name | MCC950 |
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| Description | Purity >98%. NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer's disease, and atherosclerosis. MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1Beta in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM). It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin. MCC-950 is active in vivo, blocking the production of IL-1Beta and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome. It is also active in ex vivo samples from individuals with Muckle-Wells syndrome. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide, CP 456,773 |
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| Gene, Accession, CAS # | CAS: 210826-40-7 |
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| Catalog # | LS-H8611 |
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| Order / More Info | MCC950 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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