| 产品详情 |
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| Antigenic Specificity | Cathepsin A |
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| Clone | 15D2C93 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Cathepsin A. Cathepsin A, also known as Protective Protein Cathepsin A (PPCA), is a serine carboxypeptidase that is required for correct lysosomal transportation. Cathepsin A is synthesized as a 54 kD zymogen and is processed into an enzymatically active two-chain form in lysosomes. Cathepsin A exhibits carboxypeptidase activity at acidic pH in the lysosome and acts such as deaminase and esterase at a neutral pH. It participates in the inactivation of several selected neuropeptides, which includes substance P, oxytocin, and endothelin I. Cathepsin A forms a multienzyme complex with β-galactosidase (GLB1) and neuraminidase (NEU1). It is necessary for the stability and activity for these two enzymes. Genetic defects in the CTSA gene lead to the secondary combined deficiency of GLB1 and NEU1 and cause the lysosomal storage disease galactosialidosis (GS). Cathepsin A has also been suggested to regulate chaperone-mediated autophagy through the proteolytic inactivation of Lysosome-associated membrane protein 2 (LAMP2). |
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| Immunogen | Partial Cathepsin A recombinant protein (29 - 480 a.a.) expressed in 293E cells. |
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| Other Names | CTSA, GSL, Protective Protein For Beta-Galactosidase (PPGB), GLB2, NGBE, Protective Protein Cathepsin A (PPCA), Carboxypeptidase C, Lysosomal Protective Protein, Lysosomal Carboxypeptidase A, Carboxypeptidase-L |
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| Gene, Accession # | Gene ID: 5476 |
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| Catalog # | 683902 |
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| Price | |
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| Order / More Info | Cathepsin A Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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