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| Antigenic Specificity | 5HT1A Receptor/HTR1A |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat (predicted: hamster) |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100ug (sample available) |
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| Concentration | 500ug/ml. |
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| Applications | IHC, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC-P in Human;Mouse;Rat. No cross reactivity with other proteins. HTR1A(5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor(GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ), different from the related rat and mouse sequences by one amino acid. |
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| Other Names | 5-hydroxytryptamine receptor 1A;5-HT-1A;5-HT1A;G-21;Serotonin receptor 1A;HTR1A;ADRB2RL1, ADRBRL1; |
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| Gene, Accession # | HTR1A, UniProt: P08908 |
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| Catalog # | PA1647 |
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| Price | |
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| Order / More Info | 5HT1A Receptor/HTR1A Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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