| 产品详情 |
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| Antigenic Specificity | NALCN (extracellular) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 µl |
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| Concentration | lyophilized |
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| Applications | Immunocytochemistry: 1:50, Immunofluorescence: Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:200 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NALCN (extracellular) Polyclonal Antibody. Nalcn is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Nalcn regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, Nalcn activity is enhanced/modulated by several GPCRs, is required for normal respiratory rhythm and neonatal survival, is involved in systemic osmoregulation by controlling the serum sodium concentration. Nalcn is partly responsible for the substance P-induced depolarization and regu |
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| Immunogen | n/a |
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| Other Names | Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, Four domain-type voltage-gated ion channelalpha-1 subunit |
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| Gene, Accession # | Entrez: 259232, 266760, 338370; Uniprot: Q6Q760, Q8BXR5, Q8IZF0 |
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| Catalog # | PA5-77736 |
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| Price | |
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| Order / More Info | NALCN (extracellular) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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