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Product Name | Non-cleavable Linker |
Description | Creative Biolabs can provide several noncleavable alkyl and polymeric linkers, such as the notablely successful MCC amine-to-sulfhydryl bifunctional cross-linker featured in T-DM1. This linker is especially useful as the cyclohexane ring provides steric hindrance that decreases the rate of hydrolysis of the resulting thioether. Non-cleavable thioether linkers, succinimide-thioether bonds that formed by the reaction of maleimids with thiols, have also been commonly used to link auristatin derivatives to monoclonal antibodies. |
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Order / More Info | Non-cleavable Linker from CREATIVE BIOLABS |
Product Specific References | n/a |
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