| 产品详情 |
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| Product Name | Cl-Amidine (trifluoroacetate salt) |
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| Description | Purity >95%. Cl-amidine is an inhibitor of protein arginine deiminases (PAD; IC50 s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4 in vitro, respectively). It irreversibly inactivates all four PAD subtypes (kinact /KI = 37,000, 1,200, 2,000, and 13,000 M-1 min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity. Cl-amidine is cytotoxic to HL-60, MCF7, and HT-29 cancer cell lines (IC50 s = 0.25, 0.05 and 1 µM, respectively). In a collagen-induced mouse model of inflammatory arthritis, Cl-amidine dose-dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide 2,2,2-trifluoroacetate |
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| Gene, Accession, CAS # | CAS: 1043444-18-3 |
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| Catalog # | LS-H7184 |
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| Order / More Info | Cl-Amidine (trifluoroacetate salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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