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| Product Name | Recombinant Mouse G-CSF (Animal-Free) |
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| Description | G-CSF is the key hematopoietic cytokine involved in the control of neutrophil development; therefore, it is a critical regulator of innate immunity against bacterial infections. G-CSF mobilizes stem cells indirectly by downregulating the expression of CXCL12 on marrow osteoblasts and by releasing neutrophil and monocyte proteolytic enzymes, including neutrophil elastase, cathepsin G, and matrix metalloproteinase-9. This in turn degrades important HSC-trafficking and adhesion molecules, such as c-kit, VCAM-1, and CXCR4. In addition, G-CSF possesses immunosuppressive effects on monocytes/macrophages, dendritic cells, and T lymphocytes. The receptor for G-CSF is expressed not only in hematopoietic cells but also in cardiomyocytes, skeletal muscle, and neurons. G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. In vitro, G-CSF displays strong antiapoptotic activity in neuronal cells. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Granulocyte-Colony Stimulating Factor, CSF3, CSF-β, Pluripoietin, Granulocytic neutrophil colony stimulating activity (G-CSA), Macrophage-granulocyte inducer-2 (MGI-2), GCSF |
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| Gene, Accession, CAS # | Gene ID: 12985 |
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| Catalog # | 713502 |
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| Order / More Info | Recombinant Mouse G-CSF (Animal-Free) from BIOLEGEND |
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| Product Specific References | n/a |
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