| 产品详情 |
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| Product Name | Poziotinib |
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| Description | An inhibitor of EGFRs (IC50s = 3.2, 5.3, 23.5, 4.2, and 2.2 nM for wild-type EGFR, HER2, HER4, EGFRT790M, and EGFRL858R/T790M, respectively); has greater than 100- to 1,000-fold selectivity for EGFR kinases in vitro over 30 other kinases; inhibits growth of wild-type and mutant EGFR kinase-dependent lung, breast, and gastric cancer cell lines (GI50s = 0.6-5.7 nM); inhibits EGFR phosphorylation and induces apoptosis in vitro; reduces tumor size in an HCC827 non-small cell lung cancer mouse xenograft model, |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HM781-36B |
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| Gene, Accession, CAS # | CAS: 1092364-38-9 |
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| Catalog # | 22437-10 |
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| Price | |
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| Order / More Info | Poziotinib from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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