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| Product Name | AP 24534 |
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| Description | Potent multi-kinase and pan-Bcr-Abl inhibitor. Displays potent activity against cell lines expressing native Bcr-Abl or Bcr-AblT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other Abl kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active. Purity 98%. MW (observed): 532.56 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide. Ponatinib |
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| Gene, Accession, CAS # | CAS: 943319-70-8 |
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| Catalog # | 4274/10 |
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| Order / More Info | AP 24534 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23114643, 25046000 |
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| 产品资料 |
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