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| Product Name | PDM 11 |
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| Description | Purity >98%. The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 11 is structurally very similar to several resveratrol analogs which act as a potent and selective AhR antagonists and agonists. One of these compounds, which contains fluorine in place of the 4'-chlorine of PDM11, acts as a AhR antagonist with a Ki of approximately 3 nM. This fluorine-containing compound is inactive as a ligand for the estrogen receptor even at 100 µM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, antagonists of AhR could potentially serve as therapeutic agents for the treatment for dioxin and other aryl hydrocarbon poisonings. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-5-[2-(4-chlorophenyl)ethenyl]-1,3-dimethoxyphenyl |
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| Gene, Accession, CAS # | CAS: 1032508-03-4 |
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| Catalog # | LS-H9307 |
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| Order / More Info | PDM 11 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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