| 产品详情 |
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| Antigenic Specificity | ABI1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ABI1 Polyclonal Antibody. May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level . |
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| Immunogen | n/a |
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| Other Names | ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, Abelson interactor 1, Abl-interactor protein 1 long, abl interactor 1, abl-binding protein 4, eps8 SH3 domain-binding protein, interactor protein AblBP4, nap1 binding protein, spectrin SH3 domain-binding protein 1 |
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| Gene, Accession # | Entrez: 10006, 11308, 79249; Uniprot: Q8CBW3, Q8IZP0, Q9QZM5 |
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| Catalog # | PA5-34783 |
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| Price | |
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| Order / More Info | ABI1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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