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| Antigenic Specificity | ZNRF1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ZNRF1 Polyclonal Antibody. E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). |
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| Immunogen | n/a |
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| Other Names | zinc and ring finger 1; B830022L21Rik; MGC101991; Rnf42; Zrfp1; nin283; E3 ubiquitin-protein ligase ZNRF1; nerve injury-induced gene 283 protein; peripheral nerve injury protein nin283; ring finger protein 42; zinc ring finger protein 1 |
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| Gene, Accession # | Entrez: 84937; Uniprot: Q8ND25 |
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| Catalog # | PA5-71962 |
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| Price | |
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| Order / More Info | ZNRF1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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