| 产品详情 |
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| Antigenic Specificity | ZO-1 |
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| Clone | ZO1-1A12 |
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| Host Species | Mouse |
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| Reactive Species | canine, human |
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| Isotype | IgG1 |
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| Format | Alexa Fluor 488 conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: 0.1-1.0 µg/mL (unconjugated), Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor 488. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript varian |
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| Immunogen | n/a |
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| Other Names | ZO-1, tight junction protein ZO-1, zona occludens 1, zona occludens protein 1, zonula occludens 1 protein, zonula occludens protein 1 |
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| Gene, Accession # | Entrez: 403752, 7082; Uniprot: O97758, Q07157 |
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| Catalog # | 339188 |
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| Price | |
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| Order / More Info | ZO-1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 22670221, 23610411, 23917149, 24302586, 25217631, 25566882, 26503466 |
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