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| Antigenic Specificity | ZO-1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | canine, human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 5-10 µg/mL, Immunofluorescence: 2.5 µg/mL, Immunohistochemistry (Frozen): 2 µg/mL, Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunohistochemistry: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ZO-1 Polyclonal Antibody (ZMD.437). ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distin |
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| Immunogen | n/a |
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| Other Names | ZO-1, tight junction protein ZO-1, zona occludens 1, zona occludens protein 1, zonula occludens 1 protein, zonula occludens protein 1 |
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| Gene, Accession # | Entrez: 21872, 292994, 403752, 7082; Uniprot: O97758, P39447, Q07157 |
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| Catalog # | 40-2300 |
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| Price | |
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| Order / More Info | ZO-1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 16045494, 17210245, 18177851, 19136708, 19184677, 19821483, 19828126, 19933191, 20158611, 20584329, 20616358, 21093098, 21159656, 21767321, 21905165, 21965293, 22048282, 22491404, 22815934, 23049838, 23114967, 23408941, 23740983, 24145168, 24183650, 24413171, 24590176, 24668812, 24677108, 24858797, 24919690, 24943270, 24955347, 24989888, 25220655, 25616357, 26116663, 26206859, 26528722, 26555149, 26689989, 26690704, 26935764, 26966880, 27111582, 27281648, 27357248, 27510174, 27767041, 27927890, 28084299, 28202390 |
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