| 产品详情 |
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| Antigenic Specificity | PXR |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 3.75 µg/mL, peptide-ELISA: 1:4000, Western Blot: 1-3 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PXR Polyclonal Antibody. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. |
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| Immunogen | n/a |
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| Other Names | PXR; NR1I2; nuclear receptor subfamily 1, group I, member 2; BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; SAR; SXR; orphan nuclear receptor; pregnane X receptor; steroid and xenobiotic receptor |
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| Gene, Accession # | Entrez: 8856; Uniprot: O75469 |
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| Catalog # | PA5-19080 |
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| Price | |
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| Order / More Info | PXR Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 20480272 |
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