| 产品详情 |
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| Product Name | PF-01247324 |
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| Description | An Nav1.8 sodium channel blocker (IC50 = 0.19 µM for human Nav1.8); selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 µM, respectively) as well as ERG potassium channels (IC50 = 30 µM); blocks Nav1.8 channels in a VSP-FRET assay using HEK293 cells (IC50 = 2.6 µM); reduces phase 2 flinching in a rat model of formalin-induced persistent pain at 100 mg/kg; increases latency to lift the inflamed paw and latency to paw withdrawal in rat models of carrageenan-induced thermal hyperalgesia and CFA-induced mechanical hyperalgesia, respectively |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PF01247324 TTXR VSPFRET HEK-293 |
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| Gene, Accession, CAS # | CAS: 875051-72-2 |
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| Catalog # | 22111-25 |
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| Order / More Info | PF-01247324 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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