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| Product Name | Recombinant Human parvovirus B19 Minor capsid protein VP1, partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 64.8kDa. Partial: 228-781aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Human parvovirus B19 (isolate AU) (HPV B19). Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors, such as the glycosphingolipid globoside or the integrin heterodimer ITGAV/ITGB1. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal (s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Coat protein VP1 |
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| Gene, Accession, CAS # | UniProt: P07299 |
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| Catalog # | RPC20679 |
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| Order / More Info | Recombinant Human parvovirus B19 Minor capsid protein VP1, partial from BIOMATIK |
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| Product Specific References | n/a |
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