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| Product Name | CytoSelect 96-well Cell Transformation Assay |
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| Description | Background: Neoplastic transformation occurs via a series of genetic and epigenetic alterations that yield a cell population that is capable of proliferating independently of both external and internal signals that normally restrain growth. For example, transformed cells show reduced requirements for extracellular growth promoting factors, are not restricted by cell-cell contact, and are often immortal. Anchorage-independent growth is one of the hallmarks of transformation, which is considered t |
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| Size | 24 assays, 96 assays, 480 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS169037 |
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| Order / More Info | CytoSelect 96-well Cell Transformation Assay from MYBIOSOURCE INC. |
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| Product Specific References | 1. Shin SI, Freedman VH, Risser R, and Pollack R. (1975) Proc Natl Acad Sci U S A. 72:4435-9.2. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW and Weinberg RA. (1999) Nature 400:464-8.1. Maccario, C. et al. (2012).The Resveratrol Analog 4,4'-Dihydroxy-Trans-Stilbene Suppresses Transformation in Normal Mouse Fibroblasts and Inhibits Proliferation and Invasion of Human Breast Cancer Cells. Carcinogenesis. 10.1093/carcin/bgs244.2. Maag, D. et al. (2011). Inositol Polyphosphate Multikinase is a Physiologic PI3-Kinase that Activates Akt/PKB. PNAS 108:1391-1396.3. Inami, Y. et al. (2011). Persistent Activation of Nrf2 through p62 in Hepatocellular Carcinoma Cells. J. Cell Biol. 10.1083/jcb.201102031.4. Rubio, R. et al. (2010). Deficiency in p53 but not retinoblastoma induces the transformation of mesynchymal stem cells in vitro and initiates leiomyosarcoma in vivo. Cancer Res. 70:4185-4194.5. Faoro, L. et al. (2010). EphA2 Mutation in Lung Squamous Cell Carcinoma Promotes Increased Cell Survival, Cell Invasion, Focal Adhesions, and Mammalian Target of Rapamycin Activation. J. Biol. Chem. 285:18575-185856. Iorns, E. et al. (2010). The Role of SATB1 in Breast Cancer Pathogenesis. J.Natl. Cancer Inst. 10.1093/jnci/djq243.7. Liu, F. et al. (2010). Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 29:3650-36648. Carnahan, J. (2010). Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth. Mol. Cancer Ther. 9:2399-2410.9. Kang, M-I. et al. (2009). A selective small-molecule nuclear factor-kB inhibitor from a high-throughput cell-based assay for activator protein-1 hits. Mol. Cancer Ther. 8:571-581.10. Takezawa, K. et al. (2009). Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in RKAS mutant cells. Cancer Res. 69:6515-6521.11. Lee, K.B. et al. (2008). Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases. Exp. and Mol. Medicine 40(1):118-129.12. Shen, L. et al. (2008). E1A inhibits the proliferation of human cervical cancer cells (HeLa cells) by apoptosis induction through activation of HER-2/Neu/Caspase-3 pathway. Med. Oncol. 25:222-228.13. Wei, Q. et al. (2008). Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies. PNAS 105:19738-19743.14. Gazin, C. et al. (2007). An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449(7165):1073-1077. |
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