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| Product Name | CytoSelect 96-well Leukocyte-endothelium Adhesion Kit |
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| Description | Background: Leukocyte extravasation into perivascular tissue plays a key role in inflammatory diseases. This recruitment requires leukocyte interaction with vascular endothelium and consists of multiple, consecutive processes including the capture of circulating leukocytes, subsequent leukocyte rolling, arrest, firm adhesion and transmigration (Figure 1). This multistep paradigm is realized by sequential activation-dependent interactions between endothelial cell adhesion molecules and their spec |
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| Size | 100 assays |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168873 |
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| Order / More Info | CytoSelect 96-well Leukocyte-endothelium Adhesion Kit from MYBIOSOURCE INC. |
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| Product Specific References | 1. Carlos T. Mand Harlan J. M. (1994) Blood 84, 2068-101.2. Meldrum, D. R. (1998) Am. J. Physiol. 274, R577-R595.1. Sharma-Walia, N. et al. (2014). The Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Induced 5-Lipoxygenase-Leukotriene B4 Cascade Plays Key Roles in KSHV Latency, Monocyte Recruitment, and Lipogenesis. J. Virol. 88:2131-2156.2. Avan, A. et al. (2013). Norepinephrine Increases NADPH Oxidase-Derived Superoxide in Human Peripheral Blood Mononuclear Cells via alpha-Adrenergic Receptors. Cancer Res. 73:6745-67563. Liu,G. et al. (2012). ICAM-1-activated Src and eNOS Signaling Increase Endothelial Cell Surface PECAM-1 Adhesivity and Neutrophil Transmigration. Blood. 120:1942-1952.4. Fang, Y. et al. (2012).Site-Specific MicroRNA-92a Regulation of Kruppel-Like Factors 4 and 2 in Atherosusceptible Endothelium. Arterioscler Thromb Vasc Biol. 32:979-987.5. Curatola, A.M. et al. (2012). Dehydroepiandrosterone (DHEA) Inhibition of Monocyte Binding by Vascular Endothelium is Associated with Sialylation of Neural Cell Adhesion Molecule. Reproductive Sciences 19:86-91.6. Wang, Y.L. et al. (2011). Innate Immune Function of the Adherens Junction Protein p120-Catenin in Endothelial Response to Endotoxin. J. Immunol. 186-3180-3187.7. Xue, J. et al. (2009). NFkB Regulates Thrombin-Induced ICAM-1 Gene Expression in Cooperation with NFAT by Binding to the Intronic NFkB Site in the ICAM-1 Gene. Physiol. Genomics 10.1152/physiolgenomics.00012.2009. |
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