| 产品详情 |
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| Product Name | Leptomycin B |
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| Description | Purity >98%. Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins (export factors). By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation. Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp.. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,10E,12E,16Z,18E-nonadecapentaenoic acid, Elactocin, LMB, Mantuamycin, NSC 364372 |
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| Gene, Accession, CAS # | CAS: 87081-35-4 |
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| Catalog # | LS-H8451 |
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| Price | |
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| Order / More Info | Leptomycin B from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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