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| Product Name | Recombinant Herpes simplex virus type 2 ICP47 protein (US12) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 23.9kDa. Full Length: 1-78aa. N-terminal 6xHis-KSI-tagged. Herpes simplex virus type 2 (strain SA8) (Simian agent 8). Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing, thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Immediate-early protein IE12 (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12) |
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| Gene, Accession, CAS # | US12, UniProt: P60504 |
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| Catalog # | RPC26086 |
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| Order / More Info | Recombinant Herpes simplex virus type 2 ICP47 protein (US12) from BIOMATIK |
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| Product Specific References | n/a |
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