| 产品详情 |
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| Product Name | Amyloid beta (A4) Precursor Protein (APP) (AA 22-35) peptide |
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| Description | Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. It has been demonstrated that beta amyloid (22-35) possesses a cytotoxic effect on cultured rat hippocampus neurons in serum-free medium. Aggregates and typical amyloid fibrils resembling those of the beta amyloid protein (AP) are formed in neutral buffer solution from beta amyloid (22-35). These fibrils show characteristic staining with Congo red and thioflavin-S. The neurotoxicity of beta amyloid (22-35) can be suppressed by addition of calf serum, dibutyryl cAMP, or insulin to the culture medium. However, the addition of NGF or substance P will not suppress the neurotoxicity. Beta amyloid (22-35) does not act on glial cells. These results suggest that AP can induce neurotoxicity in hippocampal cells in vitro and may result in a disorder involving intracellular signal transduction. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | APP|APP-like|APPL|Abeta|BcDNA:GH04413|CG7727|Dmel\\CG7727|EG:65F1.5|appl|aaa|abeta|abpp|ad1|appi|ctfgamma|cvap|pn2|AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|Abpp|Adap|Ag|Cvap|E030013M08Rik|betaApp|app|wu:fj34d10|wu:fk65e12|zgc:85740 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN399146 |
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| Order / More Info | Amyloid beta (A4) Precursor Protein (APP) (AA 22-35) peptide from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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