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| Product Name | Recombinant Human SWI/SNF complex subunit SMARCC1 (SMARCC1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 41.4kDa. Partial: 449-669aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Involved in transcriptional activation and repression of select genes by chromatin rodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | BRG1-associated factor 155; BAF155SWI/SNF complex 155KDA subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 |
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| Gene, Accession, CAS # | SMARCC1, UniProt: Q92922 |
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| Catalog # | RPC23322 |
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| Order / More Info | Recombinant Human SWI/SNF complex subunit SMARCC1 (SMARCC1), partial from BIOMATIK |
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| Product Specific References | n/a |
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