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| Product Name | Ascomycin |
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| Description | Purity >98%. Ascomycin, produced by the fermentation of S. hygroscopicus subsp. ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FK-506-binding protein 12 (FKBP12), an immunophilin that acts as the principal mediator of FK506- and rapamycin-induced immunosuppression. Ascomycin inhibits the enzymatic peptidyl-prolyl cis -trans isomerase and chaperone activities of PfFKBP35, an FKBP from P. falciparum, a causative agent of malaria in humans with an IC50 value of 0.52 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-py, Immunomycin, FK-520, FR900520, Changchuanmycin, L 683590 |
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| Gene, Accession, CAS # | CAS: 104987-12-4 |
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| Catalog # | LS-H6636 |
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| Order / More Info | Ascomycin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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