| 产品详情 |
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| Product Name | Ascomycin (high purity) |
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| Description | Purity >98%. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Analog of FK-506, FK520, FR-900520, Immunomycin, L-683590, NSC 106410, WS 7238A |
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| Gene, Accession, CAS # | CAS: 104987-12-4 |
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| Catalog # | LS-H469 |
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| Order / More Info | Ascomycin (high purity) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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